CONVERSION OF SERINE AND THREONINE RESIDUES INTO α-ACYLOXY-, α-ALKYLTHIO-, AND α-HALOGENOGLYCINE MOIETIES: A NEW STRATEGY FOR THE MODIFICATION OF PEPTIDES

DOI: 10.1016/S0040-4039(00)79711-5

Source and publish data:

Tetrahedron Letters p. 3163 - 3166 (1991)

Update date:2022-08-06

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Authors:

Apitz, Gregor

Steglich, Wolfgang

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Article abstract of DOI:10.1016/S0040-4039(00)79711-5

Selective modification of serine and threonine containing peptides is accomplished by oxidation with lead tetraacetate.Conversion of the derived α-acetoxyglycine derivative into α-alkylthio- and α-halogenoglycine residues offers a novel synthetic route to

Full text of DOI:10.1016/S0040-4039(00)79711-5

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