Optically active antifungal azoles. II. Synthesis and antifungal activity of polysulfide derivatives of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1- (1H-1,2,4-triazol-1-yl)-2-butanol

DOI: 10.1248/cpb.41.1043

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1043 - 1048 (1993)

Update date:2022-08-04

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Authors:

Tasaka Tasaka

Tamura Tamura

Matsushita

Hayashi Hayashi

Okonogi Okonogi

Itoh Itoh

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Article abstract of DOI:10.1248/cpb.41.1043

In an effort to find potent antifungal agents, a variety of optically active triazole derivatives with a polysulfide structure, 3, 4 and 5, were prepared and evaluated for antifungal activity against Candida albicans in vitro and in vivo. The symmetrical

Full text of DOI:10.1248/cpb.41.1043

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