HIGHLY STEREOSELECTIVE AND GENERAL SYNTHESIS OF (Z)-3-METHYL-2-ALKEN-1-OLS VIA PALLADIUM-CATALYZED CROSS COUPLING OF (Z)-3-IODO-2-BUTEN-1-OL WITH ORGANOZINCS AND OTHER ORGANOMETALS

Article abstract of DOI:10.1016/S0040-4039(00)60312-X

The reaction of Zn-protected (Z)-3-iodo-2-buten-1-ol with organozincs in the presence of 1-5 mol percent of a Pd complex, e.g., Pd(PPh3)4 or Cl2Pd(PPh3)2 and n-BuLi (2 equiv), in DMF provides a highly stereoselective (>/= 96 percent), general, and high-yi