
Tetrahedron Letters p. 1437 - 1440 (1993)
Update date:2022-08-04
Topics:
Negishi, Ei-ichi
Ay, Mehmet
Gulevich, Yuri V.
Noda, Yumiki
The reaction of Zn-protected (Z)-3-iodo-2-buten-1-ol with organozincs in the presence of 1-5 mol percent of a Pd complex, e.g., Pd(PPh3)4 or Cl2Pd(PPh3)2 and n-BuLi (2 equiv), in DMF provides a highly stereoselective (>/= 96 percent), general, and high-yi
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