Novel acyclic nucleotides and nucleoside 5'-triphosphates imitating 2',3'- dideoxy-2',3'-didehydronucleotides: Synthesis and biological properties

DOI: 10.1021/jm00048a010

Source and publish data:

Journal of Medicinal Chemistry p. 3739 - 3748 (1994)

Update date:2022-07-30

Topics:

Authors:

Shirokova

Tarussova

Shipitsin

Semizarov

Krayevsky

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Article abstract of DOI:10.1021/jm00048a010

A series of pyrophosphoryl (Z)-(phosphonomethoxy)but-2-enyl derivatives of pyrimidines and purines 9a-d and the corresponding phosphonates 10a-d were synthesized. The prepared compounds contain the phosphonate group as an α- phosphate mimic as well as an

Full text of DOI:10.1021/jm00048a010

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