Chemical and Pharmaceutical Bulletin p. 2906 - 2909 (1991)
Update date:2022-08-05
Topics:
Otsubo
Morita
Uchida
Yamasaki
Kanbe
Shimizu
The enantiomers of 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid [(±)-1, rebamipide, OPC-12759], a new antiulcer agent that enhances mucosal resistance, were synthesized from optically active α-amino acid derivatives of 2(1H)-quinolinone. The key intermediates, α-amino acid derivatives, were prepared by asymmetric synthesis and optical resolution. The (±)-1 was ahout 1.7 times as potent as the (-)-isomer in antiulcer activity against ethanol-induced gastric ulcers.
View MoreContact:+86 512 6287 2180
Address:398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
SICHUAN ZHONGBANG NEW MATERIAL CO., LTD
website:http://www.zhongbangst.com
Contact:86-830-2585019
Address:sichuan,china
TIANJIN DONGRUXIANG MINERALS MARKETING CO.,LTD(expird)
Contact:22-58516360
Address:tianjin
Contact:+86-29-88710656
Address:South Tai bai Road, High Tech Development Zone, Xi'an China
Changyi Xinxing Technology Development Co., Ltd.
Contact:0086-510-86651065(Time Zone:8),86651656
Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
Doi:10.1021/jo300339a
(2012)Doi:10.1002/adsc.201900096
(2019)Doi:10.1016/j.bmcl.2016.04.021
(2016)Doi:10.1002/ejoc.201101338
(2012)Doi:10.1021/jm950539l
(1996)Doi:10.1002/ejoc.201101712
(2012)
