Chemoselective reactioms of 14,17α-bis(hydroxymethyl)-3-methoxyestra-1,3,5(10)-trien-17β-ol. Synthesis of novel 14,17-hetero-bridged 19-norsteroids

Article abstract of DOI:10.1016/S0040-4020(01)89740-4

Chemoselective differentiation of the primary hydroxy groups in 14,17α-bis(hydroxymethyl)-3-methoxyestra-1,3,5(10)-trien-17β-ol (2) has been investigated in a series of reactions which lead inter alia to novel 14,17-hetero-bridged steroid hormone analogue