Tetrahedron Letters p. 5401 - 5404 (1991)
Update date:2022-08-05
Topics:
Bol
Liskamp
A new approach to the synthesis of alkene dipeptide isosteres is reported which features the use of the [2,3]-Wittig-Still rearrangement, carried out in hexane. As an example the synthesis of the alkene dipeptide isostere of Gly-Ala as part of the tripeptide isostere Z-Phe-GlyΨ[E-CH=CH]-(R,S)A1a-OH is described.
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