Reaction of pyranoid and furanoid aldonolactones with chloromethyltrimethylsilane-derived reagents

Article abstract of DOI:10.1016/0008-6215(91)80007-A

Reaction of pyranoid and furanoid aldonolactones with trimethylsilylmethyl-lithium provides a convenient route to carbon-chain-elongated methyl ketones. Reaction of the lactones with chloro(trimethylsilyl)methyl-lithium gives the corresponding chloromethylketones. Reaction of pyranoid and furanoid aldonolactones with trimethylsilylmethyl-lithium provides a convenient route to carbon-chain-elongated methyl ketones. Reaction of the lactones with chloro(trimethylsilyl)methyl-lithium gives the corresponding chloromethylketones.