Three-Component Cyclocondensations. An Efficient Synthesis of 4-Amino-2-(methylthio)imidazolium Salts via the Reaction of Methyl Chlorothioimidates with Benzaldimines and Isocyanides. Autoxidation of the Imidazole Derivatives

Article abstract of DOI:10.1021/jo00033a038

Treatment of imino chlorosulfides 1 with a mixture of benzaldimine and isocyanide provides 4-aminoimidazolium chlorides 5.Presumably the reaction involves the N-imidoylbenzylideniminium chlorides 4 as transient intermediates. 1- and 3-tert-Butyl imidazoli