NiCl2(PPh3)2-Zn Promoted Deallyloxycarbonylative Directed Aldol Reaction of Allyl β-Keto Carboxylates with Aldehydes th β-Hydroxy Ketones

Article abstract of DOI:10.1246/cl.1991.2023

Regio- and chemospecific deallyloxycarbonylative aldol reaction of allyl (or -lic) α,α-disubstituted β-keto carboxylate with aldehyde was effectively promoted by Ni(0) (NiCl2(PPh3)2-Zn), in which the allyloxycarbonyl group (-COOCH2CH=CH2) was replaced to 1-hydroxyalkyl group (-CH(OH)R, R=alkyl, vinyl, aryl) under mild reaction conditions.