Tetrahedron Letters p. 7445 - 7448 (1991)
Update date:2022-08-04
Topics:
Tanaka, Hideo
Kameyama, Yutaka
Kosaka, Atsuko
Yamauchi, Takahito
Torii, Sigeru
A convenient synthesis of 2-exo-methylene penams 1 was performed by transformation of thiazoline-azetidinones, derived from penicillin G, through intramolecular Michael addition. Manipulation of the exo-methylene moiety of 1 opened new entries to 2-oxopenam and 2β-thiomethyl substituted penams, respectively.
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