A Novel Skeletal Rearrangement of 2-Azabicyclohept-5-ene-3-carboxylic Acid Derivatives into 2-Oxabicyclo-oct-7-en-3-ones under Acidic Conditions

Article abstract of DOI:10.1246/bcsj.65.61

The reaction of ethyl 2-azabicyclo<2.2.1>hept-5-ene-3-carboxylate with aroyl chloride and the subsequent hydrolysis of the ester group provided 2-aroyl-2-azabicyclo<2.2.1>hept-5-ene-3-carboxylic acid derivatives, which underwent a stereospecific rearrange