Synthesis of 9-[2',3'-dideoxy-2',3'-bis-C-hydroxymethyl-α-L-threofuranosyl] adenine and its 4'-thio analog as potential antiviral agents

Article abstract of DOI:10.1016/S0040-4039(97)01035-6

The enantiomerically pure synthesis or 9-[2',3'-dideoxy-2',3'-bis-C-hydroxymethyl-α-L- threofuranosyl]adenine and its 4'-thio analog was achieved via coupling of silylated 6-chloropurine with 1-O-acetylfuronase derivative 17 and its 4'-thio analog 24, respectively, prepared from (+)-diethyl L-tartrate.