Efficient synthesis of tetrahydroquinolinones by acetic acid-mediated formal [3+3] cycloaddition

Article abstract of DOI:10.1007/s00706-012-0762-0

A simple and efficient method to synthesize a variety of tetrahydroquinolinones was successfully achieved by reacting various β-enaminones with several α,β-unsaturated aldehydes. This strategy can be viewed as a Bronsted acid-mediated formal [3+3] cycloaddition. Springer-Verlag 2012.