A CONVENIENT SYNTHESIS OF 3(2)-TRIFLUOROACETYLAMINOBENZOTHIOPHENES AND THIOPHENES AND SOME OF THEIR IODO DERIVATIVES

Article abstract of DOI:10.3987/COM-91-5907

Trifluoroacetylamino derivatives of benzothiophene and thiophene (3a-d) have been obtained by Curtius rearrangement of the corresponding acyl azides (1a-d) with trifluoroacetic acid.The iodination of these amide derivatives with iodine under mild conditions leads to iodinated products in excellent yield, except in the case of the 3-trifluoroacetylaminobenzothiophene (3a), which only gives a polymeric residue.