Bioorganic and Medicinal Chemistry Letters p. 625 - 630 (1996)
Update date:2022-09-26
Topics:
Fink, David M.
Palermo
Bores, Gina M.
Huger, Francis P.
Kurys, Barbara E.
Merriman, Michael C.
Olsen, Gordon E.
Petko, Wayne
O'Malley, Gerard J.
A series of imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates was prepared and evaluated as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen substitution ortho to the carbamate functionality in the eight position resulted in a significant increase in binding affinity for both AChE and MAO-A.
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