Synthesis of N3-substituted carboranyl thymidine bioconjugates and their evaluation as substrates of recombinant human thymidine kinase 1

DOI: 10.1016/j.ejmech.2012.11.041

Source and publish data:

European Journal of Medicinal Chemistry p. 456 - 468 (2013)

Update date:2022-08-15

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Authors:

Agarwal, Hitesh K.

McElroy, Craig A.

Sjuvarsson, Elena

Eriksson, Staffan

Darby, Michael V.

Tjarks, Werner

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Article abstract of DOI:10.1016/j.ejmech.2012.11.041

Four different libraries of overall twenty three N3-substituted thymidine (dThd) analogues, including eleven 3-carboranyl thymidine analogues (3CTAs), were synthesized. The latter are potential agents for Boron Neutron Capture Therapy (BNCT) of cancer. Li

Full text of DOI:10.1016/j.ejmech.2012.11.041

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