SN2′ selective alkylation of allylic chlorides and mesylates with RZnX reagents generated from Grignard reagents, zinc chloride, lithium chloride, and Cu(II)-salts

Article abstract of DOI:10.1016/S0040-4039(00)60534-8

Treatment of RMgX (1 equiv. R = alkyl; X = Cl, Br) with ZnCl₂ (1 equiv.) in a mixed solvent of THF and Et₂O leads to a highly turbid white suspension. Addition of LiCl (1～2 equiv.) solubilizes the insoluble species to yield a colorless clear solution. Addition of a catalytic amount of a Cu(II)-.