Zirconium catalyzed chemoselective synthesis of new amido-substituted benzo[b]furans via a one-pot reaction

Article abstract of DOI:10.3987/COM-12-12621

A one-pot, three-component reaction of arylglyoxals, benzamide and phenols using catalytic amounts of zirconium oxychloride octahydrate under solvent-free conditions produce new amido-substituted benzo[b]furans. The reactions showed chemoselectivity towards benzofuran instead of oxazols which this claim has been confirmed by nuclear magnetic resonance (NMR) and infrared spectroscopy (IR).

Full text of DOI:10.3987/COM-12-12621

ZIRCONIUM CATALYZED CEMOSELECTIVE SYNTHESIS OF
NEW AMIDO-SUBSTITUTED BENZO[b]FURANS VIA A ONE-
POT REACTION
Bahador Karami, Saeed Khodabakhshi and Hamid Reza Vahabinia
Department of Chemistry, Yasouj University, Yasouj, Zip Code: 75918-74831
P.O.Box 353, Iran
*E-mail: karami@mail.yu.ac.ir
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Br
O
HN
O
Ph
10

Br
O
HN
O
Ph
11

O
HN
O
Ph
12

O
HN
O
Ph
13

O
HN
O
Ph
14

OMe
Ph
NH
O
O
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OMe
Ph
NH
O
O
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OMe
Ph
NH
O
O
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Cl
Ph
O
NH
O
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Cl
Ph
O
NH
O
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Cl
Ph
O
NH
O
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