Leucine-phenylalanine dipeptide-based N-mesyloxysuccinimides: Synthesis of all four stereoisomers and their assay against serine proteases

DOI: 10.1016/S0960-894X(99)00017-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 497 - 500 (1999)

Update date:2022-08-02

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Authors:

Abell, Andrew D.

Oldham, Mark D.

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Article abstract of DOI:10.1016/S0960-894X(99)00017-7

The four stereoisomers of 3-(N-acetylleucylamino)-3-benzyl-1- [(methylsulfonyl)oxy]succinimide have been prepared and shown to inhibit α- chymotrypsin and human neutrophil elastase. The structural and stereochemical features that affect the potency and selectivity of inhibition are discussed.

Full text of DOI:10.1016/S0960-894X(99)00017-7

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