Leucine-phenylalanine dipeptide-based N-mesyloxysuccinimides: Synthesis of all four stereoisomers and their assay against serine proteases

DOI: 10.1016/S0960-894X(99)00017-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 497 - 500 (1999)

Update date:2022-08-02

Topics:

Authors:

Abell, Andrew D.

Oldham, Mark D.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00017-7

The four stereoisomers of 3-(N-acetylleucylamino)-3-benzyl-1- [(methylsulfonyl)oxy]succinimide have been prepared and shown to inhibit α- chymotrypsin and human neutrophil elastase. The structural and stereochemical features that affect the potency and selectivity of inhibition are discussed.

Full text of DOI:10.1016/S0960-894X(99)00017-7

Products guided by the article

Product name:(2R,4S)-4-Benzhydryloxycarbonylmethyl-4-benzyl-5-oxo-2-phenyl-oxazolidine-3-carboxylic acid benzyl ester

Cas No:145440-43-3

R&D Labs maybe for 145440-43-3

XI'AN CHUKANG BIOTECHNOLOGY CO.,LTD

Contact:29-63685658 63685359

Address:Room 3-1202,Building 1,Oriental oasis,East of Xianning Road,Xi'an,Shaanxi 710043 P.R.China
wuxi huabin bio-tech Co.,Ltd(expird)

Contact:86-0510-85133006

Address:hubin road NO157
Weifang Jahwa Chemical Co.,Ltd

Contact:0086-536-8897731,8897730

Address:No.5166 East Dongfeng Street,Weifang,Shandong,China
Suzhou Lixin Pharmaceutical Co., Ltd.

Contact:86-512-88169812

Address:21 Tangxi Road, Suzhou New District, Suzhou 215151
Sino-Japan Chemical Co., Ltd.

website:http://www.sjc.com.tw

Contact:(886) 2-2396-6223

Address:14Fl., No. 99. Sec. 2, Jen Ai Road

Relevant to this article

The design of dipeptide helical mimetics, Part I: The synthesis of 1,6-disubstituted indanes

Doi:10.1016/0040-4020(94)00887-Z
(1995)
Scandium-bipyridine-catalyzed enantioselective addition of alcohols and amines to meso-epoxides

Doi:10.1002/anie.200460786
(2004)
170. Reactions of 2-Monosubstituted 3-Amino-2H-azirines with NH-Acidic Heterocycles

Doi:10.1002/hlca.19920750713
(1992)
Synthesis of sitagliptin phosphate by a NaBH₄/ZnCl₂-catalyzed diastereoselective reduction

Doi:10.1246/cl.150390
(2015)
Access to cyclic α-CF₃-substituted α-amino acid derivatives by ring-closing metathesis of functionalized 1,7-enynes

Doi:10.1002/ejoc.201300619
(2013)
Easy and rapid preparation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase

Doi:10.1016/j.bmcl.2017.03.017
(2017)

Article Doi