Leucine-phenylalanine dipeptide-based N-mesyloxysuccinimides: Synthesis of all four stereoisomers and their assay against serine proteases

DOI: 10.1016/S0960-894X(99)00017-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 497 - 500 (1999)

Update date:2022-08-02

Topics:

Authors:

Abell, Andrew D.

Oldham, Mark D.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00017-7

The four stereoisomers of 3-(N-acetylleucylamino)-3-benzyl-1- [(methylsulfonyl)oxy]succinimide have been prepared and shown to inhibit α- chymotrypsin and human neutrophil elastase. The structural and stereochemical features that affect the potency and selectivity of inhibition are discussed.

Full text of DOI:10.1016/S0960-894X(99)00017-7

Products guided by the article

Product name:(2R,4S)-4-Benzhydryloxycarbonylmethyl-4-benzyl-5-oxo-2-phenyl-oxazolidine-3-carboxylic acid benzyl ester

Cas No:145440-43-3

R&D Labs maybe for 145440-43-3

SunaTech Inc.

Contact:+86 512 6287 2180

Address:398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
Langchem

Contact:+86+21-58956006 15800617331

Address:402 Room, 150# Cailun Road, Zhangjiang high tech park, Shanghai
Beijing Chemdow Co., Ltd

website:http://www.chemdow.com

Contact:0086-10-82435335

Address:Room 401,Unit 3,4th Floor,Shangdijiayuan,Shangdi East Road, Haidian District,Beijing
Changsha Kamer Essence and Flavor Co.,Ltd

Contact:86-731-89832270

Address:No.327 Kangnin Road Changsha Bio Information Industry Park, Changsha city, Hunan province
APOLLO HEALTHCARE RESOURCES

Contact:+65 9658 0999

Address:26 Sin Ming Lane, Midview City, #05-118, Singapore 573971

Relevant to this article

The design of dipeptide helical mimetics, Part I: The synthesis of 1,6-disubstituted indanes

Doi:10.1016/0040-4020(94)00887-Z
(1995)
Scandium-bipyridine-catalyzed enantioselective addition of alcohols and amines to meso-epoxides

Doi:10.1002/anie.200460786
(2004)
170. Reactions of 2-Monosubstituted 3-Amino-2H-azirines with NH-Acidic Heterocycles

Doi:10.1002/hlca.19920750713
(1992)
Synthesis of sitagliptin phosphate by a NaBH₄/ZnCl₂-catalyzed diastereoselective reduction

Doi:10.1246/cl.150390
(2015)
Access to cyclic α-CF₃-substituted α-amino acid derivatives by ring-closing metathesis of functionalized 1,7-enynes

Doi:10.1002/ejoc.201300619
(2013)
Easy and rapid preparation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase

Doi:10.1016/j.bmcl.2017.03.017
(2017)

Article Doi