Synthesis and Use of the n-Bromododecane-1,12-diols as Conformational Probes for General Anesthetic Target Sites

Article abstract of DOI:10.1021/jm00053a014

The n-bromododecane-1,12-diols with bromine on carbons 2, 3, 5, and 6, respectively, were synthesized and found to be potent general anesthetics.They were also found to be potent inhibitors of firefly luciferase, a protein model for the primary target sit