Syntheses of 13C- and 14C-labelled trans-2-amino-2-methyl-N-(4-nitroxycyclohexyl)-propionamide (BM 12.1179)

Article abstract of DOI:10.1002/ardp.19923251109

The ¹³C- and ¹⁴C-labelled derivatives of the vasodilating nitric acid ester trans-2-amino-2-methyl-N-(4-nitroxycyclohexyl)-propionamide (BM 12.1179) (1) have been synthesized starting from the sterically hindered α-amino-isobutyric acid (2) via the oxazolone (synthesis of ¹³C-BM 12.1179) and the acid chloride (synthesis of ¹⁴C-BM 12.1179). Various amine-protecting groups and methods for activating the carboxy-function are compared.