(E)-4-amino>phenoxy>butyric Acid Derivatives: A New Class of Steroid 5α-Reductase Inhibitors in the Rat Prostate. 1

DOI: 10.1021/jm00015a011

Source and publish data:

Journal of Medicinal Chemistry p. 2887 - 2892 (1995)

Update date:2022-08-03

Topics:

Authors:

Kumazawa, Toshiaki

Takami, Hitoshi

Kishibayashi, Nobuyuki

Ishii, Akio

Nagahara, Yoshitomo

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00015a011

A series of (E)-4-<2-<<3-(indol-5-yl)-1-oxo-2-butenyl>amino>phenoxy>butyric acid derivatives was prepared, and the derivatives were demonstrated to be potent inhibitors of steroid 5α-reductase in the rat prostate.The structure - activity relationships wer

Full text of DOI:10.1021/jm00015a011

Products guided by the article

Product name:(E)-3-[1-(Phenyl-pyridin-4-yl-methyl)-1H-indol-5-yl]-but-2-enoic acid

Cas No:146328-01-0

R&D Labs maybe for 146328-01-0

LinHai Cina Chemical Co., LTD.

Contact:0576-85580989

Address:Pharma-chem zone,Duqiao,Linhai,Zhejiang,China
Hefei Highzone Fine Chemical S&T CO.,LTD

Contact:86-0551-63663560

Address:room 1801 NO. 24 Shuguang RD.
Shanghai Normway Pharmachem Co.,Ltd.

Contact:86-21-50897098 13501889356

Address:2F No. 450 Husong Road Minhang District Shanghai China
Liaoning Yufeng Chemical Co.,Ltd.

Contact:86-0419-3418888

Address:The metallurgical industrial zone,shoushan town, Liaoyang, Liaoning, China
Tianjin Dongchang Fine Chemical Industry Co., Ltd.

Contact:+86-22-29894595

Address:Economic Developing Zone, Ji County, Tianjin, China

Relevant to this article

Novel Base-promoted Addition-Elimination Reaction of Electron-deficient Benzylidene Derivatives with N-Phenyl-1,2,4-triazole-3,5-dione (PTAD)

Doi:10.1039/c39910000089
(1991)
Unprotected Amino Acids as Stable Radical Precursors for Heterocycle C-H Functionalization

Doi:10.1021/acs.orglett.6b01754
(2016)
Synthesis of Pyrrole Derivatives from 5,6-Dihydro-4H-1,2-oxazines via Reductive Deoxygenation by Use of Fe3(CO)12

Doi:10.1246/bcsj.63.3595
(1990)
Metal nitrite: A powerful oxidizing reagent

Doi:10.1021/ja206736q
(2011)
CATALYTIC ASYMMETRIC EPOXIDATION OF UNFUNCTIONALIZED OLEFINS

Doi:10.1016/S0040-4039(00)88562-7
(1990)
Reformatsky Reaction: Carboxymethylenation of Cyclic Anhydrides and Reactions of Products Thereof

Doi:10.1021/jo00007a061
(1991)

Article Doi