(E)-4-amino>phenoxy>butyric Acid Derivatives: A New Class of Steroid 5α-Reductase Inhibitors in the Rat Prostate. 1

DOI: 10.1021/jm00015a011

Source and publish data:

Journal of Medicinal Chemistry p. 2887 - 2892 (1995)

Update date:2022-08-03

Topics:

Authors:

Kumazawa, Toshiaki

Takami, Hitoshi

Kishibayashi, Nobuyuki

Ishii, Akio

Nagahara, Yoshitomo

et al. et al.

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Article abstract of DOI:10.1021/jm00015a011

A series of (E)-4-<2-<<3-(indol-5-yl)-1-oxo-2-butenyl>amino>phenoxy>butyric acid derivatives was prepared, and the derivatives were demonstrated to be potent inhibitors of steroid 5α-reductase in the rat prostate.The structure - activity relationships wer

Full text of DOI:10.1021/jm00015a011

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