SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL N-1-ARYL-6-FLUORO-5-METHYL-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS

DOI: 10.3987/COM-92-6121

Source and publish data:

Heterocycles p. 2301 - 2311 (1992)

Update date:2022-08-04

Topics:

Authors:

Jacquet, Jean-Pierre

Bouzard, Daniel

Cesare, Pierre Di

Dolnic, Nicolas

Massoudi, Massoud

Remuzon, Philippe

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Article abstract of DOI:10.3987/COM-92-6121

A series of 5-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acids was prepared in which the N-1 position was substituted by various aryl groups.Seven compounds showed excellent in vitro antibacterial activity against Gram-positive and Gram-negative strains.

Full text of DOI:10.3987/COM-92-6121

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