Specific sequestering agents for the actinides. 21. Synthesis and initial biological testing of octadentate mixed catecholate-hydroxypyridinonate ligands

DOI: 10.1021/jm00056a011

Source and publish data:

Journal of Medicinal Chemistry p. 504 - 509 (1993)

Update date:2022-08-04

Topics:

Authors:

Uhlir Uhlir

Durbin Durbin

Jeung Jeung

Raymond Raymond

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Article abstract of DOI:10.1021/jm00056a011

The linear octadentate ligand 3,4,3-LIHOPO, which contains four 1-hydroxy- 2(1H)-pyridinone (1,2-HOPO) groups, is the most effective agent for in vivo chelation of Pu(IV) yet prepared. However, its clinical potential is limited by acute toxicity of the fr

Full text of DOI:10.1021/jm00056a011

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