A new synthesis of 24-fluoro-1α,25-dihydroxyvitamin D2 and its 24-epimer, and determination of the C-24 configuration

DOI: 10.1248/cpb.40.2932

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2932 - 2936 (1992)

Update date:2022-08-02

Topics:

Authors:

Hayashi Hayashi

Ojima Ojima

Konno Konno

Manaka Manaka

Yamaguchi

Yamada Yamada

Takayama

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Article abstract of DOI:10.1248/cpb.40.2932

A new synthesis of 24-fluoro-1α,25-dihydroxyvitamin D₂ (4a) and its 24-epimer (4b) is described. Starting with 1α,3β-bis[(tert-butyldimethylsilyl)oxy]-24-norchol-5,7-dien-23-al (5), a mixture of 4a and 4b was obtained in 3% overall yield in 6 s

Full text of DOI:10.1248/cpb.40.2932

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