Tandem nucleophilic reaction leading to hydrofurans: Application to one- pot synthesis of antitumor naphthofuran natural product

DOI: 10.3987/COM-98-8430

Source and publish data:

Heterocycles p. 497 - 500 (1999)

Update date:2022-08-03

Topics:

Authors:

Hagiwara, Hisahiro

Sato, Kouji

Suzuki, Toshio

Ando, Masayoshi

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Article abstract of DOI:10.3987/COM-98-8430

The reaction of enolates of 1,3-dicarbonyl compounds (1) with 3,4- dibromo-2-butanone (2) afforded hydrofuran derivatives (4) or (5) in the presence of DBU in THF and the reaction was applied to the one-pot synthesis of antitumor naphthofuran products (29).

Full text of DOI:10.3987/COM-98-8430

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