Tandem nucleophilic reaction leading to hydrofurans: Application to one- pot synthesis of antitumor naphthofuran natural product

Article abstract of DOI:10.3987/COM-98-8430

The reaction of enolates of 1,3-dicarbonyl compounds (1) with 3,4- dibromo-2-butanone (2) afforded hydrofuran derivatives (4) or (5) in the presence of DBU in THF and the reaction was applied to the one-pot synthesis of antitumor naphthofuran products (29).