Enantioconvergent Synthesis of a Promising HMG Co-A Reductase Inhibitor NK-104 from Both Enantiomers of Epichlorohydrin

DOI: 10.1016/S0957-4166(00)82337-X

Source and publish data:

Tetrahedron Asymmetry p. 201 - 204 (1993)

Update date:2022-08-05

Topics:

Authors:

Takano, Seiichi

Kamikubo, Takashi

Sugihara, Takumichi

Suzuki, Mikio

Ogasawara, Kunio

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0957-4166(00)82337-X

An enantioconvergent synthesis of (+)-NK-104 (3), a promising HMG Co-A reductase inhibitor, has been developed from both enantiomers of epichlorohydrin.

Full text of DOI:10.1016/S0957-4166(00)82337-X

Products guided by the article

Product name:2-Cyclopropyl-4-(4-fluoro-phenyl)-3-phenylsulfanylmethyl-quinoline

Cas No:148516-12-5

R&D Labs maybe for 148516-12-5

Hangzhou Gangjin Chemical Co.,Ltd.(expird)

Contact:+86-571-85109780

Address:707 Zhejiang Minhang Bldg., No.290 Zhongshan North Road, Hangzhou 310003, China
Linyi Shengxin Pharmaceutical R&D Co., Ltd

Contact:+86-18653953873

Address:West First of Yufeng Road, Yishui County
Nanjing Samwon International Limited

Contact:+86-25-84873444

Address:1108, BLDG B, New Century Plaza, No 1, South Taiping Rd.,
JiangXi Keyuan Biopharma Co., LTD.

Contact:+86-563-6833666

Address:Guangde Fine Chemical Zone, Anhui Province, China
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd

Contact:028-85317716

Address:Tianfu Life Science Park, No. 88 South Keyuan Road, Gaoxin District, Chengdu City, Sichuan Province, PRC.

Relevant to this article

INTRAMOLECULAR EXCHANGE IN TERTIARY PHOSPHINE DERIVATIVES OF DODECACARBONYLTRIOSMIUM

Doi:10.1016/0022-328X(85)87133-3
(1985)
Photoamination of 2-Alkoxynaphthalenes with Alkylamines via Electron Transfer and Its Application to Synthesis of 1-Alkylamino-2-tetralones

Doi:10.1246/bcsj.67.246
(1994)
Hemisynthesis and structural and chromatic characterization of delphinidin 3- O -glucoside-vescalagin hybrid pigments

Doi:10.1021/jf4033188
(2013)
Pyrazole-based cathepsin S inhibitors with improved cellular potency

Doi:10.1016/j.bmcl.2007.08.038
(2007)
Catalytic Enantioselective Aza-pinacol Rearrangement

Doi:10.1002/anie.201705539
(2017)
Synthesis and photochemical behaviour of 4-nitroimidazoles in the presence of oxygen

Doi:10.1016/S0040-4020(01)90240-6
(1993)

Article Doi