Structure-activity relationship of a series of phenylureas linked to 4- phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O- acyltransferase with antiatherosclerotic activity. 2

DOI: 10.1021/jm00063a014

Source and publish data:

Journal of Medicinal Chemistry p. 1641 - 1653 (1993)

Update date:2022-07-30

Topics:

Authors:

Kimura Kimura

Watanabe

Matsui Matsui

Hayashi Hayashi

Tanaka Tanaka

Ohtsuka Ohtsuka

Saeki Saeki

Kogushi Kogushi

Kabayashi

Akasaka Akasaka

Yamagishi

Saitou Saitou

Yamatsu Yamatsu

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Article abstract of DOI:10.1021/jm00063a014

In our continuing search to find systemically bioavailable ACAT (acyl- CoA:cholesterol O-acyl-transferase) inhibitors with more potent antiatherosclerotic effect than N-[2-(dimethylamino)-6-[3-(5-methyl-4- phenyl-1H-imidazol-1-yl)propoxy]phenyl]-N'-pentyl

Full text of DOI:10.1021/jm00063a014

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