Total synthesis of the cembranoid diterpene lactone (+)-cleomeolide. Some remarkable conformational features of nine-membered belts linked in 2,6-fashion to a methylenecyclohexane core

Article abstract of DOI:10.1021/ja00087a023

The total synthesis of (+)-cleomeolide (1) has been accomplished. The key construction elements of this cembranoid lactone were (i) improved conversion of optically pure Wieland-Miescher ketone into dienol ether 12 and oxidative cleavage of the latter to