Total synthesis of the cembranoid diterpene lactone (+)-cleomeolide. Some remarkable conformational features of nine-membered belts linked in 2,6-fashion to a methylenecyclohexane core

DOI: 10.1021/ja00087a023

Source and publish data:

Journal of the American Chemical Society p. 3367 - 3374 (1994)

Update date:2022-08-05

Topics: Total synthesis

Authors:

Paquette, Leo A.

Wang, Ting-Zhong

Philippo, Christophe M. G.

Wang, Shaopeng

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Article abstract of DOI:10.1021/ja00087a023

The total synthesis of (+)-cleomeolide (1) has been accomplished. The key construction elements of this cembranoid lactone were (i) improved conversion of optically pure Wieland-Miescher ketone into dienol ether 12 and oxidative cleavage of the latter to

Full text of DOI:10.1021/ja00087a023

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