Aminoacyl analogs of chloramphenicol: Examination of the kinetics of inhibition of peptide bond formation

Article abstract of DOI:10.1021/jm00075a008

Two aminoacyl analogs and one peptidyl analog of chloramphenicol (1, Cl₂CHCO-CA) were prepared. These are 2 (L-Phe-CA), 3 (Gly-CA), and 4 (L- Phe-Gly-CA). The kinetics of inhibition of peptide bond formation by these analogs were examined in a