Bioorganic and Medicinal Chemistry p. 623 - 630 (1997)
Update date:2022-08-04
Topics:
Nagamura, Satoru
Asai, Akira
Kobayashi, Eiji
Gomi, Katsushige
Saito, Hiromitsu
New duocarmycin SA derivatives have been synthesized and evaluated for in vitro anticellular activity against HeLa S3 cells, and in vivo antitumor activity against murine sarcoma 180 in mice. The results suggested that the N,N-dialkylcarbamoyl derivatives bearing the p-methoxy cinnamoyl group, which was prepared from duocarmycin SA, showed good in vivo antitumor activities superior to native duocarmycin SA.
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