Studies on duocarmycin SA and its derivatives

Article abstract of DOI:10.1016/S0968-0896(96)00276-3

New duocarmycin SA derivatives have been synthesized and evaluated for in vitro anticellular activity against HeLa S₃ cells, and in vivo antitumor activity against murine sarcoma 180 in mice. The results suggested that the N,N-dialkylcarbamoyl derivatives bearing the p-methoxy cinnamoyl group, which was prepared from duocarmycin SA, showed good in vivo antitumor activities superior to native duocarmycin SA.