Tetrahedron Letters p. 6859 - 6862 (1993)
Update date:2022-08-03
Topics:
Niederer, Daniel A.
Kapron, James T.
Vederas, John C.
N-Cbz-3-phenyloxaziridine can be generated in a two step process.This is a new reagent for direct electrophilic N-amination of chiral α-amino acids and their derivatives which affords the corresponding hydrazino acids protected with a readily removable N-Cbz group.Application of this methodology to a facile synthesis of L-hydrazino serine, a potentially useful biological tool, is described.
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Doi:10.1016/S0040-4020(02)01487-4
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