Synthetic approach to aphidicolan and stemodan basic skeletons using a "Tandem Principle" [2+2+2] and [4+2] cycloaddition reactions

Article abstract of DOI:10.1016/0040-4039(94)85068-2

A strategy based upon the "Tandem Principle" : coupling of the cobalt catalyzed [2+2+2] cycloaddition and an intramolecular [4+2] Diels-Alder reaction allowed the formation of the stemodan skeleton in 11 high yield steps starting from 4-ethoxycarbonyl cyclohexanone.