Regiospecificity in the cyclization of 6-(1-hydroxyalkyl) geraniol derivatives. A simple route to the taxol A-ring system

Article abstract of DOI:10.1016/S0040-4039(00)76737-2

Readily available derivatives of geraniol bearing a 1-hydroxyalkyl side chain in the 6-position undergo acid-catalyzed regiospecific cyclization to form cyclogeraniol derivatives which have an interesting relation to ring A of taxol.