Asymmetric synthesis. XXXI. Synthesis of 2-substituted piperazines from chiral non-racemic lactams

DOI: 10.1016/S0040-4039(00)77163-2

Source and publish data:

Tetrahedron Letters p. 2533 - 2536 (1994)

Update date:2022-07-29

Topics:

Authors:

Schanen, Vincent

Riche, Claude

Chiaroni, Angele

Quirion, Jean-Charles

Husson, Henri-Philippe

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Article abstract of DOI:10.1016/S0040-4039(00)77163-2

The preparation of lactam 2 from R-(-)-phenylglycinol and N-Boc glycine is described. Diastereoselective alkylation of 2 allowed the preparation of piperazine derivatives in an optically pure form.

Full text of DOI:10.1016/S0040-4039(00)77163-2

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Product name:(R)-2-((R)-3-Methyl-piperazin-1-yl)-2-phenyl-ethanol

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