The Utility of 2,5-Dideoxy-2,5-imino-D-mannitol as a PFP Enzyme Inhibitor

Article abstract of DOI:10.1016/S0957-4166(00)86301-6

2,5-Dideoxy-2,5-imino-D-mannitol was synthesized from an arabinofuranose derivative.Mercuric acetate cyclization of an ene-carbamate was the key step.The compound proved to be an inhibitor of the pyrophosphate-fructose-6-phosphate-1-phosphotransferase (PFP) enzyme and has potential utility in the biorational design of herbicides.