Chemoenzymatic synthesis of (+)-docosa-4,15-dien-l-yn-3-ol, a component of the marine sponge Cribrochalina vasculum, and confirmation of the structure, and absolute configuration of the acetylenic alcohol, by lipase-catalysed biotransformations

Article abstract of DOI:10.1039/a807681b

The (4E,15Z)-, and (4￡,15￡)-isomers of (+)-docosa-4,15-dien-l-yn-3-ol 1, isolated from the marine sponge Cribroclialina vasculwn, were synthesized in highly enantiomerically pure form by lipase-mediated biotransformation with Novozym 435, and the structur