SN2'-Reactions of Peptide Aziridines. A Cuprate-Based Approach to (E)-Alkene Isosteres

Article abstract of DOI:10.1021/jo00096a033

Alkenylaziridines were prepared from allylic alcohols via Sharpless epoxidation, oxirane to aziridine conversion under modified Staudinger conditions, and Wittig chain extension.Alternatively, β-hydroxy α-amino acids such as threonine can serve as readily