Syntheses of Antitumor Morphinane Alkaloids, Sinococuline and 6-epi-, 7-epi-, and 6-epi-7-epi-Sinococuline, from Sinomenine

DOI: 10.1021/jo00119a037

Source and publish data:

Journal of Organic Chemistry p. 4549 - 4558 (1995)

Update date:2022-07-30

Topics:

Authors:

Hitotsuyanagi, Yukio

Nishimura, Kunihiko

Ikuta, Hiroshi

Takeya, Koichi

Itokawa, Hideji

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Article abstract of DOI:10.1021/jo00119a037

An antitumor alkaloid, sinococuline 81), and its C-6 and/or C-7 epimeric analogs 3-5 have been synthesized from sinomenine (2).The carbonyl transposition from 9 to 8 using selenoxide chemistry proceeded in an efficient manner.Successive C-6 hydroxylation

Full text of DOI:10.1021/jo00119a037

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