Synthesis of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides as potential antiviral agents

Article abstract of DOI:10.1080/07328319908044878

A series of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides has been synthesized as potential antiviral agents. The synthesized compounds were evaluated against HIV-1, HBV, HSV-1, and HSV-2. Among the synthesized analogues, only the cytosine derivative showed moderate antiviral activity against HIV and HBV.

Full text of DOI:10.1080/07328319908044878

Nucleosides and Nucleotides
ISSN: 0732-8311 (Print) (Online) Journal homepage: http://www.tandfonline.com/loi/lncn19
Synthesis of 2′,3′-Dideoxy-2′-Fluoro-l-threo-
Pentofuranosyl Nucleosides as Potential Antiviral
Agents
Socrates C. H. Cavalcanti , Yuejun Xiang , M. Gary Newton , Raymond F.
Schinazi , Yung-Chi Cheng & Chung K. Chu
To cite this article: Socrates C. H. Cavalcanti , Yuejun Xiang , M. Gary Newton , Raymond F.
Schinazi , Yung-Chi Cheng & Chung K. Chu (1999) Synthesis of 2′,3′-Dideoxy-2′-Fluoro-l-threo-
Pentofuranosyl Nucleosides as Potential Antiviral Agents, Nucleosides and Nucleotides, 18:10,
2233-2252, DOI: 10.1080/07328319908044878
To link to this article: http://dx.doi.org/10.1080/07328319908044878
Published online: 04 Oct 2006.
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Date: 28 January 2016, At: 18:53