Nucleosides and Nucleotides p. 2233 - 2252 (1999)
Update date:2022-09-26
Topics:
Cavalcanti, Socrates C. H.
Xiang, Yuejun
Newton, M. Gary
Schinazi, Raymond F.
Cheng, Yung-Chi
Chu, Chung K.
A series of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides has been synthesized as potential antiviral agents. The synthesized compounds were evaluated against HIV-1, HBV, HSV-1, and HSV-2. Among the synthesized analogues, only the cytosine derivative showed moderate antiviral activity against HIV and HBV.
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