
Tetrahedron Letters p. 4279 - 4282 (1995)
Update date:2022-08-05
Topics:
Convery, Maire A.
Davis, Anthony P.
Dunne, Ciaran J.
MacKinnon, John W.
The enantiopure bicyclic amidine bases 5a-c were synthesized from alcohol 8, via alkylation of the appropriate nitriles. The phenylsulphonylamidine 5a was subjected to X-ray crystallography as its nitrate salt, and was shown by 1H NMR to differentiate analytically between the enantiomers of chiral carboxylic acids.
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