Synthesis and properties of enantiopure bicyclic amidines

DOI: 10.1016/0040-4039(95)00739-Y

Source and publish data:

Tetrahedron Letters p. 4279 - 4282 (1995)

Update date:2022-08-05

Topics:

Authors:

Convery, Maire A.

Davis, Anthony P.

Dunne, Ciaran J.

MacKinnon, John W.

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Article abstract of DOI:10.1016/0040-4039(95)00739-Y

The enantiopure bicyclic amidine bases 5a-c were synthesized from alcohol 8, via alkylation of the appropriate nitriles. The phenylsulphonylamidine 5a was subjected to X-ray crystallography as its nitrate salt, and was shown by ¹H NMR to differentiate analytically between the enantiomers of chiral carboxylic acids.

Full text of DOI:10.1016/0040-4039(95)00739-Y

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