Journal of Medicinal Chemistry p. 3297 - 3312 (1995)
Update date:2022-08-05
Topics:
Froestl
Mickel
Hall
Von Sprecher
Strub
Baumann
Brugger
Gentsch
Jaekel
Olpe
Rihs
Vassout
Waldmeier
Bittiger
The antispastic agent and muscle relaxant baclofen 1 is a potent and selective agonist for bicuculline-insensitive GABA(B) receptors. For many years efforts to obtain superior GABA(B) agonists were unsuccessful. We describe the syntheses and biological pr
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