Chemical and Pharmaceutical Bulletin p. 1234 - 1237 (1995)
Update date:2022-08-03
Topics:
Ravina
Cid
Negreira
Castro
Moldes
G-Ferreiro
Rosa
MaCalleja
De Ceballos
Starting from the methyl ester of β-(bromomethyl)-γ-phenylbutyric acid and its m-fluoro derivative, we have prepared 2-[4-[3-(p-fluorobenzoyl)-1- propyl]piperazin-1-ylmethyl]tetraline (QF0105B) and the corresponding 7- fluoro derivative (QF0106B). The affinities of these compounds for D1 and D2 dopamine and 5-HT(2A) receptors was evaluated in vitro. The affinities of QF0105B and QF0106B for D2 receptors are less than that of haloperidol (pK(i)'s for inhibition of [3H]spiperone binding: 7.72, 7.06 and 8.30, respectively) but all three compounds have similar affinities for 5-HT(2A) receptors (pK(i)'s for inhibition of [3H]ketanserine binding: 7.70, 7.36 and 7.70, respectively).
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Doi:10.1021/ja00132a005
(1995)Doi:10.1021/jo00121a035
(1995)Doi:10.1007/s11172-007-0240-8
(2007)Doi:10.1021/jo00800a035
(1971)Doi:10.1016/0040-4039(95)00785-B
(1995)Doi:10.1016/0040-4020(96)00691-6
(1996)
