Journal of Organic Chemistry p. 7334 - 7339 (1995)
Update date:2022-08-03
Topics:
Pommier
Pons
Kocienski
A key step in the first total synthesis of the potent pancreatic lipase inhibitor (-)-lipstatin (1) is a diastereoselective Lewis acid-promoted [2 + 2] cycloaddition reaction between n-hexyl(trimethylsilyl)ketene (4) and (R)-(-)-(Z,Z)-3-[(tert-butyldimethylsilyl)oxy]-5,8-tetradecadienal (3), which is prepared from dimethyl (S)-(-)-malate.
View Morechangsha chenjin chemical technology co.,LtD(expird)
Contact:86-731-84451263
Address:Room 201/217-218, 101 Jingyuan Electronic Technology Co.,Ltd. Testing Center, No.69, Lufeng Road, High-tech Development Zone, Changsha, China
Contact:86-21-58226973
Address:No 351,Guoshoujing Road, Zhangjiang Hi-tech Park, Pudong, Shanghai, China
Hangzhou jls Flame Retardants Chemical Co.,Ltd
Contact:+86-571-87250387/87250386
Address:MOGANSHAN RODA 1418# SHANGCHENG INDUSTRIAL PARK
chengdu firsterchem Pharmaceutical Co., Ltd.
Contact:028-66825849
Address:chengdu
Changyi Xinxing Technology Development Co., Ltd.
Contact:0086-510-86651065(Time Zone:8),86651656
Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
Doi:10.1080/00397919508011826
(1995)Doi:10.1021/acs.orglett.8b00071
(2018)Doi:10.1016/0022-328X(95)00311-D
(1995)Doi:10.1002/chem.202001902
(2020)Doi:10.1021/jacs.7b12673
(2018)Doi:10.1002/jhet.5570320419
(1995)
