Journal of Organic Chemistry p. 7334 - 7339 (1995)
Update date:2022-08-03
Topics:
Pommier
Pons
Kocienski
A key step in the first total synthesis of the potent pancreatic lipase inhibitor (-)-lipstatin (1) is a diastereoselective Lewis acid-promoted [2 + 2] cycloaddition reaction between n-hexyl(trimethylsilyl)ketene (4) and (R)-(-)-(Z,Z)-3-[(tert-butyldimethylsilyl)oxy]-5,8-tetradecadienal (3), which is prepared from dimethyl (S)-(-)-malate.
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Doi:10.1080/00397919508011826
(1995)Doi:10.1021/acs.orglett.8b00071
(2018)Doi:10.1016/0022-328X(95)00311-D
(1995)Doi:10.1002/chem.202001902
(2020)Doi:10.1021/jacs.7b12673
(2018)Doi:10.1002/jhet.5570320419
(1995)
