C32-amino derivatives of the immunosuppressant ascomycin

DOI: 10.1016/S0960-894X(97)00409-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2199 - 2204 (1997)

Update date:2022-08-04

Topics:

Authors:

Ok, Hyun O.

Szumiloski, John L.

Beattie, Thomas R.

Goulet, Mark T.

Staruch, Mary Jo

Dumont, Francis J.

Wyvratt, Matthew J.

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Article abstract of DOI:10.1016/S0960-894X(97)00409-5

Various C32-amino derivatives were investigated as replacements for the C32-hydroxyl group of ascomycin and its C24-deoxy analog. The syntheses of these amino derivatives and their biological evaluation are reported herein.

Full text of DOI:10.1016/S0960-894X(97)00409-5

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