Journal of Antibiotics p. 1467 - 1480 (1995)
Update date:2022-08-04
Topics:
Sakai
Kawai
Kamishohara
Odagawa
Suzuki
Uchida
Kawasaki
Tsuruo
Otake
New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.
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