Synthesis of Bestatin, a Potent Inhibitor of Leukotriene A4 Hydrolase, by an N3 Nucleophile Reaction to a Non-protected Diol

Article abstract of DOI:10.1271/bbb.60.534

The synthesis of bestatin (1), based on the regio-selective introduction of a nitrogen function to a non-protected diol 9, is described.

Full text of DOI:10.1271/bbb.60.534

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Bioscience, Biotechnology, and Biochemistry
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Synthesis of Bestatin, a Potent Inhibitor of
Leukotriene A4 Hydrolase, by an N3 Nucleophile
Reaction to a Non-protected Diol
Koshi Kosekia, Takashi Ebataa & Hajime Matsushitaa
a Japan Tobacco Inc., Life Science Research Laboratory, 6–2 Umegaoka, Aoba-ku,
Yokohama, Kanagawa 227, Japan
Published online: 12 Jun 2014.
To cite this article: Koshi Koseki, Takashi Ebata & Hajime Matsushita (1996) Synthesis of Bestatin, a Potent Inhibitor
of Leukotriene A4 Hydrolase, by an N3 Nucleophile Reaction to a Non-protected Diol, Bioscience, Biotechnology, and
Biochemistry, 60:3, 534-536, DOI: 10.1271/bbb.60.534
To link to this article: http://dx.doi.org/10.1271/bbb.60.534
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