Reduction of nitriles into aldehydes using a TMDS/V(O)(OiPr)3 reducing system

DOI: 10.1016/j.tetlet.2013.10.065

Source and publish data:

Tetrahedron Letters p. 23 - 26 (2014)

Update date:2022-07-30

Topics:

Authors:

Laval, Stéphane

Dayoub, Wissam

Pehlivan, Leyla

Métay, Estelle

Delbrayelle, Dominique

Mignani, Gérard

Lemaire, Marc

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Article abstract of DOI:10.1016/j.tetlet.2013.10.065

A simple and convenient method for the chemoselective reduction of nitriles into aldehydes using a 1,1,3,3-tetramethyldisiloxane (TMDS)/ triisopropoxyvanadium(V) oxide reducing system is described. Aromatic as well as aliphatic nitriles are reduced into the corresponding aldehydes in moderate to good yields.

Full text of DOI:10.1016/j.tetlet.2013.10.065

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