Synthesis and radiation stability of novel thiazolopyrimidines with expected antifungal activity

Article abstract of DOI:10.1080/10426509608029657

A number of thiazolopyrimidines (II-VII) were prepared through interaction of 6-methyl-4(4′-chlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5- carboxylic acid ethyl ester (Ia) with many reagents. The antifungal activity of all prepared compounds have been determined using Dithane M-45 as a standard fungicide. Some compounds showed a high fungicidal activity equivalent to that of the standard towards Aspergillus niger and Aspergillus ochraceus. Also some biologically active compounds were subjected to gamma irradiation and the structures are stable.

Full text of DOI:10.1080/10426509608029657

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Phosphorus, Sulfur, and Silicon and
the Related Elements
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SYNTHESIS AND RADIATION
STABILITY OF NOVEL
THIAZOLOPYRIMIDINES WITH
EXPECTED ANTIFUNGAL ACTIVITY
M. M. Ghorab a , Y. A. Mohamed b , S. A. Mohamed b & Y. A.
Ammar b
a Department of Drug Radiation Research, National Center
for Radiation Research and Technology, Atomic Energy
Authority, Cairo, Egypt
b Department of Chemistry, Faculty of Science, Al-Azhar
University, Cairo, Egypt
Published online: 24 Sep 2006.
To cite this article: M. M. Ghorab , Y. A. Mohamed , S. A. Mohamed & Y. A. Ammar (1996):
SYNTHESIS AND RADIATION STABILITY OF NOVEL THIAZOLOPYRIMIDINES WITH EXPECTED
ANTIFUNGAL ACTIVITY, Phosphorus, Sulfur, and Silicon and the Related Elements, 108:1-4,
249-256
To link to this article: http://dx.doi.org/10.1080/10426509608029657
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